Origin of measles virus: divergence from rinderpest virus between the 11th and 12th centuries
Open Access
- 4 March 2010
- journal article
- research article
- Published by Springer Science and Business Media LLC in Virology Journal
- Vol. 7 (1), 1-4
- https://doi.org/10.1186/1743-422x-7-52
Abstract
Measles, caused by measles virus (MeV), is a common infection in children. MeV is a member of the genus Morbillivirus and is most closely related to rinderpest virus (RPV), which is a pathogen of cattle. MeV is thought to have evolved in an environment where cattle and humans lived in close proximity. Understanding the evolutionary history of MeV could answer questions related to divergence times of MeV and RPV. We investigated divergence times using relaxed clock Bayesian phylogenetics. Our estimates reveal that MeV had an evolutionary rate of 6.0 - 6.5 × 10-4 substitutions/site/year. It was concluded that the divergence time of the most recent common ancestor of current MeV was the early 20th century. And, divergence between MeV and RPV occurred around the 11th to 12th centuries. The result was unexpected because emergence of MeV was previously considered to have occurred in the prehistoric age. MeV may have originated from virus of non-human species and caused emerging infectious diseases around the 11th to 12th centuries. In such cases, investigating measles would give important information about the course of emerging infectious diseases.This publication has 26 references indexed in Scilit:
- Reassessing conflicting evolutionary histories of the Paramyxoviridae and the origins of respiroviruses with Bayesian multigene phylogeniesInfection, Genetics and Evolution, 2010
- Resolving the impact of waiting time distributions on the persistence of measlesJournal of The Royal Society Interface, 2009
- The Evolutionary and Epidemiological Dynamics of the ParamyxoviridaeJournal of Molecular Evolution, 2008
- BEAST: Bayesian evolutionary analysis by sampling treesBMC Evolutionary Biology, 2007
- Relaxed Phylogenetics and Dating with ConfidencePLoS Biology, 2006
- The modern molecular clockNature Reviews Genetics, 2003
- Rates of Molecular Evolution in RNA Viruses: A Quantitative Phylogenetic AnalysisJournal of Molecular Evolution, 2002
- AIDS as a Zoonosis: Scientific and Public Health ImplicationsScience, 2000
- Modelling the persistence of measlesTrends in Microbiology, 1997
- Measles endemicity in insular populations: Critical community size and its evolutionary implicationJournal of Theoretical Biology, 1966