A straightforward approach towards 5-substituted thiazolylpeptides via the thio-Ugi-reaction
- 7 October 2010
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Organic & Biomolecular Chemistry
- Vol. 8 (23), 5442-5447
- https://doi.org/10.1039/c0ob00453g
Abstract
A wide range of 5-substituted thiazoles are easily accessible via cross coupling of thiazolyl triflates. These activated thiazoles can be obtained by Ugi reactions using thioacids (thio-Ugi-reaction) and subsequent cyclisation of the endo thiopeptides formed with triflic anhydride. In addition, cyclisations with acyl halides give rise to 5-acyloxysubstituted derivatives.This publication has 50 references indexed in Scilit:
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