Regulation of Human β-Defensins by Gastric Epithelial Cells in Response to Infection withHelicobacter pylorior Stimulation with Interleukin-1
Open Access
- 1 September 2000
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 68 (9), 5412-5415
- https://doi.org/10.1128/iai.68.9.5412-5415.2000
Abstract
Gastric epithelial cells in vitro and in vivo are shown to constitutively express the peptide antibiotic human β-defensin type 1 (hBD-1). In contrast, hBD-2 expression is regulated in gastric epithelial cells and increases in response to infection withHelicobacter pylorior stimulation with the proinflammatory cytokine interleukin-1. These data suggest that hBD-2 is a component of the regulated host gastric epithelial cell response toH. pyloriinfection and proinflammatory mediators.Keywords
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