PRDM9 points the zinc finger at meiotic recombination hotspots
Open Access
- 1 January 2010
- journal article
- editorial
- Published by Springer Science and Business Media LLC in Genome Biology
- Vol. 11 (2), 104
- https://doi.org/10.1186/gb-2010-11-2-104
Abstract
Meiotic recombination events are spread nonrandomly across eukaryotic genomes in 'hotspots'. Recent work shows that a unique histone methyltransferase, PRDM9, determines their distribution.This publication has 12 references indexed in Scilit:
- Prdm9 Controls Activation of Mammalian Recombination HotspotsScience, 2010
- Drive Against Hotspot Motifs in Primates Implicates the PRDM9 Gene in Meiotic RecombinationScience, 2010
- Accelerated Evolution of the Prdm9 Speciation Gene across Diverse Metazoan TaxaPLoS Genetics, 2009
- A Single Peptide–MHC Complex Positively Selects a Diverse and Specific CD8 T Cell RepertoireScience, 2009
- Distinct histone modifications define initiation and repair of meiotic recombination in the mouseThe EMBO Journal, 2009
- Histone H3 lysine 4 trimethylation marks meiotic recombination initiation sitesThe EMBO Journal, 2008
- Probing Meiotic Recombination DecisionsDevelopmental Cell, 2008
- A common sequence motif associated with recombination hot spots and genome instability in humansNature Genetics, 2008
- A Fine-Scale Map of Recombination Rates and Hotspots Across the Human GenomeScience, 2005
- Where the crossovers are: recombination distributions in mammalsNature Reviews Genetics, 2004