Progression of salivary gland dysfunction in patients with Sjogren's syndrome
- 30 June 2006
- journal article
- Published by BMJ in Annals Of The Rheumatic Diseases
- Vol. 66 (1), 107-112
- https://doi.org/10.1136/ard.2006.052647
Abstract
Salivary gland dysfunction is one of the key manifestations of Sjögren's syndrome. (1) To assess prospectively loss of function of individual salivary glands in patients with primary and secondary Sjögren's syndrome in relation to disease duration and use of immunomodulatory drugs. (2) To study changes in sialochemical and laboratory values and subjective complaints over time. 60 patients with Sjögren's syndrome were included in this study. Whole and gland-specific saliva (parotid and submandibular/sublingual (SM/SL)), samples were collected at baseline and after a mean of 3.6 (SD 2.3) years of follow-up. Disease duration was recorded for all patients. Patients with Sjögren's syndrome with short disease duration had significantly higher stimulated flow rates at baseline than those with longer disease duration (pSM/SL), which shows a further decrease over time, regardless of the use of DMARDs or steroids. Patients with Sjögren's syndrome with longer disease duration are characterised by severely reduced secretions of both the parotid and SM/SL glands. These observations are relevant for identifying patients who would most likely benefit from intervention treatment.Keywords
This publication has 27 references indexed in Scilit:
- Variability of flow rate when collecting stimulated human parotid salivaEuropean Journal of Oral Sciences, 2005
- Sjögren's syndrome: the diagnostic potential of early oral manifestations preceding hyposalivation/xerostomiaJournal of Oral Pathology & Medicine, 2004
- Classification criteria for Sjogren's syndrome: a revised version of the European criteria proposed by the American-European Consensus GroupAnnals Of The Rheumatic Diseases, 2002
- Reversibility of histological and immunohistological abnormalities in sublabial salivary gland biopsy specimens following treatment with corticosteroids in Sjogren's syndromeAnnals Of The Rheumatic Diseases, 2001
- Human glandular salivas: their separate collection and analysisEuropean Journal of Oral Sciences, 1996
- Long‐term followup of patients with Sjögren's syndromeArthritis & Rheumatism, 1996
- Applicability of Saliva as a Diagnostic Fluid in Sjögren's SyndromeAnnals of the New York Academy of Sciences, 1993
- PROGRESSION OF SIALADENITIS IN SJÖGREN'S SYNDROMERheumatology, 1993
- Follow up study of labial salivary gland lesions in primary Sjogren's syndrome.Annals Of The Rheumatic Diseases, 1992
- Sialochemistry in Sjögren's syndrome: a reviewJournal of Oral Pathology & Medicine, 1989