Immunophenotypic heterogeneity of multiple myeloma: influence on the biology and clinical course of the disease
- 1 February 1991
- journal article
- Published by Wiley in British Journal of Haematology
- Vol. 77 (2), 185-190
- https://doi.org/10.1111/j.1365-2141.1991.tb07975.x
Abstract
In 112 untreated myeloma patients we have analysed the immunophenotype of plasma cells both by immunofluorescence (IF) and immunocytochemistry (APAAP). Both techniques yielded similar results pointing to aH important degree of heterogeneity in antigenic expression not only between different patients but also within the same patient. The expression of CD38 and Han-PCl antigens (Ags) was almost constant (> 90% positive cases), while CD9 was detected in 66% of the cases. On the other hand, less than one third of patients were positive for CD 10, CD20 and HLA-DR and generally with a weak expression (< 30% positive plasma cells). In occasional cases plasma cells were weakly positive for the myelomonocytic markers CD13 (9%), CD15 (25%) and CD14 (6%). The possibility that this heterogeneity might be the result of different stages of differentiation of the neoplastic clone is suggested both by the positive correlation in the expression of some of these antigens (CD10, CD9, CD20, HLA-DR) and by the relationship between CD10 and myeloid antigens with immature plasma cell morphology. Finally, the cALLA antigen does not seem to be of significant value in predicting survival. Moreover, none of the other markers explored showed a clear influence in the course of the disease, although the tendency towards a lower survival found for the CD20+ cases as well as the association of the expression of some antigens and advanced clinical stage, may warrant further studies in a larger series of patients.Keywords
This publication has 14 references indexed in Scilit:
- Markers of Multiple Hematopoietic-Cell Lineages in Multiple MyelomaNew England Journal of Medicine, 1990
- Analysis of surface antigen expression of human immunoglobulin‐secreting cells: phenotypic heterogeneity in normal counterparts of myeloma cellsBritish Journal of Haematology, 1989
- CD10-(CALLA)-Positive Lymphocytes in Myeloma: Evidence that they are a Malignant Precursor Population and are of Germinal Centre OriginLeukemia & Lymphoma, 1989
- Bone marrow histopathologic patterns and immunologic phenotype in B-cell chronic lymphocytic leukaemiaBlut: Zeitschrift für die Gesamte Blutforschung, 1988
- Different reactivity of monoclonal antibodies against common acute lymphoblastic leukaemia antigen (CD10).Journal of Clinical Pathology, 1987
- Immunological phenotype of neoplasms involving the B cell in the last step of differentiationBritish Journal of Haematology, 1986
- Identification of malignant plasma cell precursors in the bone marrow of multiple myeloma.JCI Insight, 1985
- Surface Expression of Human Myeloma Cells: An Analysis Using a Panel of Monoclonal AntibodiesActa Haematologica, 1984
- A clinical staging system for multiple myeloma correlation of measured myeloma cell mass with presenting clinical features, response to treatment, and survivalCancer, 1975
- Nonparametric Estimation from Incomplete ObservationsJournal of the American Statistical Association, 1958