The Renaissance of Natural Products as Drug Candidates
Top Cited Papers
- 21 October 2005
- journal article
- perspective
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 310 (5747), 451-453
- https://doi.org/10.1126/science.1116364
Abstract
In recent years, the use of natural products for drug discovery has declined in favor of combinatorial methods and the rapid generation of large libraries of potential lead compounds. In their Perspective, Paterson and Anderson suggest that it may be time to revisit the prevailing dogma and consider ways in which natural products could continue to inspire the development of new drugs. Natural products offer high potency and selectivity as a result of long evolutionary selection. Taking bioactive natural substances as a starting point, researchers can then use the methods of organic synthesis to design targeted modifications of specific structures to create new therapeutic agents.Keywords
This publication has 15 references indexed in Scilit:
- Natural products to drugs: natural product derived compounds in clinical trialsNatural Product Reports, 2005
- The evolving role of natural products in drug discoveryNature Reviews Drug Discovery, 2005
- Macrocyclic ketone analogues of halichondrin BBioorganic & Medicinal Chemistry Letters, 2004
- Discovery of Potent Cell Migration Inhibitors through Total Synthesis: Lessons from Structure−Activity Studies of (+)-MigrastatinJournal of the American Chemical Society, 2004
- Function Oriented Synthesis: The Design, Synthesis, PKC Binding and Translocation Activity of a New Bryostatin AnalogCurrent Drug Discovery Technologies, 2004
- A Planning Strategy for Diversity‐Oriented SynthesisAngewandte Chemie-International Edition, 2003
- Natural Products as Sources of New Drugs over the Period 1981−2002Journal of Natural Products, 2003
- Emergence of diverse biochemical activities in evolutionarily conserved structural scaffolds of proteinsCurrent Opinion in Chemical Biology, 2003
- Estimating the number of protein foldsJournal of Molecular Biology, 1998
- Total synthesis of halichondrin B and norhalichondrin BJournal of the American Chemical Society, 1992