Immune Thrombocytopenic Purpura Secondary to Cytomegalovirus Infection: A Case Report
Open Access
- 3 November 2015
- journal article
- case report
- Published by Frontiers Media SA in Frontiers in Medicine
Abstract
Immune Thrombocytopenic Purpura (ITP) is defined as an acquired thrombocytopenia with antibodies detected against platelet surface antigens, and it is the most common form of thrombocytopenia in otherwise asymptomatic adults. ITP secondary to an underlying condition is a diagnosis of exclusion that is essential to establish for treatment efficacy. Secondary thrombocytopenia caused by Cytomegalovirus (CMV) is common, however case reports associated with diagnosis in immunocompetent adults are rare, and to the best of our knowledge only 20 publications have been associated with this diagnosis. Our report is based on a clinical presentation of a 37 year old female complaining of petechiae, heavy menses, shortness of breath and a platelet count of 1 X 109 /L. Treatment with IVIG and steroids failed to improve platelet count. Subsequently, an infectious laboratory workup was performed, detecting CMV infection, and treatment with antiviral agents was initiated, causing platelet count to increase as viral load decreased.This publication has 15 references indexed in Scilit:
- Cytomegalovirus can make immune thrombocytopenic purpura refractoryBritish Journal of Haematology, 2009
- Severe cytomegalovirus infection in apparently immunocompetent patients: a systematic reviewVirology Journal, 2008
- Cytomegalovirus-associated idiopathic thrombocytopenic purpura in Chinese childrenScandinavian Journal of Infectious Diseases, 2008
- Viral-Associated Immune Thrombocytopenic PurpuraHematology, 2008
- Cytomegalovirus-associated Immune Thrombocytopenic Purpura After Liver TransplantationJournal of the Formosan Medical Association, 2007
- New therapeutic options for adult chronic immune thrombocytopenic purpura: a brief reviewVox Sanguinis, 2007
- AMG 531, a Thrombopoiesis-Stimulating Protein, for Chronic ITPThe New England Journal of Medicine, 2006
- An open‐label, unit dose‐finding study of AMG 531, a novel thrombopoiesis‐stimulating peptibody, in patients with immune thrombocytopenic purpuraBritish Journal of Haematology, 2006
- VIRUS-ASSOCIATED IMMUNE THROMBOCYTOPENIC PURPURA IN CHILDHOODPediatric Hematology and Oncology, 2002
- Acute Cholestatic Hepatitis by Cytomegalovirus in an Immunocompetent Patient Resolved With GanciclovirJournal of Clinical Gastroenterology, 1999