Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies
Top Cited Papers
- 6 October 2008
- journal article
- research article
- Published by Springer Science and Business Media LLC in Journal of Neural Transmission
- Vol. 115 (11), 1573-1585
- https://doi.org/10.1007/s00702-008-0119-3
Abstract
A genome-wide association (GWA) study with pooled DNA in adult attention-deficit/hyperactivity disorder (ADHD) employing ~500K SNP markers identifies novel risk genes and reveals remarkable overlap with findings from recent GWA scans in substance use disorders. Comparison with results from our previously reported high-resolution linkage scan in extended pedigrees confirms several chromosomal loci, including 16q23.1-24.3 which also reached genome-wide significance in a recent meta-analysis of seven linkage studies (Zhou et al. in Am J Med Genet Part B, 2008). The findings provide additional support for a common effect of genes coding for cell adhesion molecules (e.g., CDH13, ASTN2) and regulators of synaptic plasticity (e.g., CTNNA2, KALRN) despite the complex multifactorial etiologies of adult ADHD and addiction vulnerability.This publication has 56 references indexed in Scilit:
- Genome-Wide Association for Methamphetamine DependenceArchives of General Psychiatry, 2008
- “Higher order” addiction molecular genetics: Convergent data from genome-wide association in humans and miceBiochemical Pharmacology, 2008
- Genome‐wide quantitative trait locus association scan of general cognitive ability using pooled DNA and 500K single nucleotide polymorphism microarraysGenes, Brain and Behavior, 2007
- A whole genome association study of neuroticism using DNA poolingMolecular Psychiatry, 2007
- Genome-Wide Association Analysis Identifies Loci for Type 2 Diabetes and Triglyceride LevelsScience, 2007
- GRB10 binds to LRP6, the Wnt co-receptor and inhibits canonical Wnt signaling pathwayBiochemical and Biophysical Research Communications, 2007
- CSMD1 Is a Novel Multiple Domain Complement-Regulatory Protein Highly Expressed in the Central Nervous System and Epithelial TissuesPublished by The American Association of Immunologists ,2006
- RhoA and Rac mediate endothelial cell polarization and detachment induced by T‐cadherinThe FASEB Journal, 2005
- Attention-Deficit/Hyperactivity Disorder in a Population Isolate: Linkage to Loci at 4q13.2, 5q33.3, 11q22, and 17p11American Journal of Human Genetics, 2004
- Mice that lack astrotactin have slowed neuronal migrationDevelopment, 2002