Antifungal Amide from Leaves of Piper hispidum
- 24 April 1998
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 61 (5), 637-639
- https://doi.org/10.1021/np9703656
Abstract
Bioactivity-guided fractionation of a CH2Cl2 extract from leaves of Piper hispidum (Piperaceae) yielded a new pyrrolidine amide, N-[7-(3‘,4‘-methylenedioxyphenyl)-2(Z),4(Z)-heptadienoyl] pyrrolidine 1, in addition to two known amides N-[5-(3‘,4‘-methylenedioxyphenyl)-2(E)-pentadienoyl] pyrrolidine and N-[2-(3‘,4‘-methylenedioxy-6‘-methoxyphenyl)-2(Z)-propenoyl]pyrrolidine. The structure of compound 1 was elucidated by interpretation of spectral data, including ES−MS. Compound 1 showed antifungal activity against Cladosporium sphaerospermum.Keywords
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