Regioselective Synthesis of Benzimidazolones via Cascade C–N Coupling of Monosubstituted Ureas
Open Access
- 27 June 2014
- journal article
- research article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 16 (14), 3844-3846
- https://doi.org/10.1021/ol501531q
Abstract
A direct method for the regioselective construction of benzimidazolones is reported wherein a single palladium catalyst is employed to couple monosubstituted urea substrates with differentially substituted 1,2-dihaloaromatic systems. In this method, the catalyst is able to promote a cascade of two discrete chemoselective C-N bond-forming processes that allows the highly selective and predictable formation of complex heterocycles from simple, readily available starting materials.Keywords
Funding Information
- National Institutes of Health (GM099817, GM58160)
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