A functional genetic variation of adenosine deaminase affects the duration and intensity of deep sleep in humans
Open Access
- 12 October 2005
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences of the United States of America
- Vol. 102 (43), 15676-15681
- https://doi.org/10.1073/pnas.0505414102
Abstract
Slow, rhythmic oscillations (2A receptor gene, which was associated with interindividual differences in anxiety symptoms after caffeine intake in healthy volunteers, affects the electroencephalogram during sleep and wakefulness in a non-state-specific manner. Our findings indicate a direct role of adenosine in human sleep homeostasis. Moreover, our data suggest that genetic variability in the adenosinergic system contributes to the interindividual variability in brain electrical activity during sleep and wakefulness.Keywords
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