When epigenetics kills: MLL fusion proteins in leukemia
- 1 March 2005
- journal article
- review article
- Published by Wiley in Hematological Oncology
- Vol. 23 (1), 1-9
- https://doi.org/10.1002/hon.739
Abstract
Chromosomal aberrations that affect the MLL (Mixed Lineage Leukemia) gene at the locus 11q23 are associated with an aggressive subtype of leukemia. These alterations create MLL fusion derivatives with an active transforming potential. This review summarizes recent advances in our knowledge about normal and malignant MLL proteins with special emphasis on epigenetic processes affected by these molecules. Copyright © 2005 John Wiley & Sons, Ltd.Keywords
This publication has 86 references indexed in Scilit:
- Therapy-related acute myeloid leukemia–like MLL rearrangements are induced by etoposide in primary human CD34+ cells and remain stable after clonal expansionBlood, 2005
- The Molecular Basis of LeukemiaHematology-American Society Hematology Education Program, 2004
- Expression analyses identify MLL as a prominent target of 11q23 amplification and support an etiologic role for MLL gain of function in myeloid malignanciesBlood, 2004
- Gene expression signatures in MLL-rearranged T-lineage and B-precursor acute leukemias: dominance of HOX dysregulationBlood, 2003
- Prognostic Significance of Partial Tandem Duplications of the MLL Gene in Adult Patients 16 to 60 Years Old With Acute Myeloid Leukemia and Normal Cytogenetics: A Study of the Acute Myeloid Leukemia Study Group UlmJournal of Clinical Oncology, 2002
- MLL amplification in myeloid malignanciesCancer Genetics and Cytogenetics, 2002
- Molecular mechanisms of leukemogenesis mediated by MLL fusion proteinsOncogene, 2001
- Leukemias related to treatment with DNA topoisomerase II inhibitors*Medical and Pediatric Oncology, 2001
- Meis1, a PBX1-Related Homeobox Gene Involved in Myeloid Leukemia in BXH-2 MiceMolecular and Cellular Biology, 1995
- Significance of a (4; 11) translocation in acute lymphoblastic leukemiaCancer, 1982