Antibody responses in primary HIV-1 infection
- 1 January 2008
- journal article
- Published by Ovid Technologies (Wolters Kluwer Health) in Current Opinion in HIV and AIDS
- Vol. 3 (1), 45-51
- https://doi.org/10.1097/coh.0b013e3282f310ae
Abstract
Purpose of review HIV-1 establishes persistent infections characterized by high levels of viral replication. This finding is remarkable given the presence of apparently vigorous HIV-specific cellular and humoral immune responses. We review the dynamics of antibody responses and viral escape from these responses during primary HIV-1 infection. Recent findings Many B cell dysfunctions appear early in HIV-1 infection, and compromise humoral responses to HIV-1 and other pathogens. The rate of viral escape from autologous neutralization varies greatly between individuals with primary HIV-1 infection, and is on average higher than the rate of escape in chronically infected individuals. Mutations, changes in glycosylation and insertions and deletions in the viral envelope may all contribute to viral escape. There may be differences in neutralization sensitivity and evolution of neutralization escape between different HIV-1 subtypes. Although several broadly neutralizing monoclonal antibodies have been identified, the factors that contribute to the development of broad heterologous responses remain unclear. Summary The rapid escape of HIV-1 in response to neutralizing antibodies and the plethora of B cell dysfunctions that occur during HIV infection pose significant obstacles to the design of an effective HIV-1 vaccine. The study of large cohorts of individuals enrolled during primary HIV-1 infection using high-throughput immunoassays, sequencing of the virus and the host, and new statistical tools may help to elucidate the pathways of viral escape, to elicit broadly neutralizing antibody responses, and to suggest means of minimizing the impact of HIV-1 on humoral immunity.Keywords
This publication has 89 references indexed in Scilit:
- Broad HIV-1 neutralization mediated by CD4-binding site antibodiesNature Medicine, 2007
- Dissecting the Neutralizing Antibody Specificities of Broadly Neutralizing Sera from Human Immunodeficiency Virus Type 1-Infected DonorsJournal of Virology, 2007
- Complement Lysis Activity in Autologous Plasma Is Associated with Lower Viral Loads during the Acute Phase of HIV-1 InfectionPLoS Medicine, 2006
- Antibody vs. HIV in a clash of evolutionary titansProceedings of the National Academy of Sciences of the United States of America, 2005
- Antibody neutralization and escape by HIV-1Nature, 2003
- Rapid evolution of the neutralizing antibody response to HIV type 1 infectionProceedings of the National Academy of Sciences of the United States of America, 2003
- The antiviral activity of antibodies in vitro and in vivoAdvances in Immunology, 2001
- HIV-1 antibody — debris or virion?Nature Medicine, 1997
- Cervicovaginal Overproduction of Specific IgG to Human Immunodeficiency Virus (HIV) Contrasts with Normal or Impaired IgA Local Response in HIV InfectionThe Journal of Infectious Diseases, 1995
- Rapid development of isolate-specific neutralizing antibodies after primary HIV-1 infection and consequent emergence of virus variants which resist neutralization by autologous seraAIDS, 1990