Identification of a Novel Thyroid Hormone Receptor Expressed in the Mammalian Central Nervous System
- 25 September 1987
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 237 (4822), 1610-1614
- https://doi.org/10.1126/science.3629259
Abstract
A complementary DNA clone derived from rat brain messenger RNA has been isolated on the basis of homology to the human thyroid hormone receptor gene. Expression of this complementary DNA produces a high-affinity binding protein for thyroid hormones. Sequence analysis and the mapping of this gene to a distinct human genetic locus indicate the existence of multiple human thyroid hormone receptors. Messenger RNA from this gene is expressed in a tissue-specific fashion with highest levels in the central nervous system.This publication has 26 references indexed in Scilit:
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