Inhibition of catecholamine Uptake2 by steroids in the isolated rat heart
Open Access
- 1 November 1970
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 40 (3), 528-530
- https://doi.org/10.1111/j.1476-5381.1970.tb10637.x
Abstract
Various steroids (1 7-fl-oestradiol, cortico-sterone, deoxycorticosterone, progesterone, testosterone and androsterone) produced a dose-dependent inhibition of the uptake of 3H-noradrenaline by the Uptake2 mechanism in the isolated perfused heart. It is suggested that these results may explain the potentiating effects of such steroids on the responses of vascular smooth muscle to catecholamines.Keywords
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