Effects of Protracted Irradiation in the Blood-forming Organs of the Rat. Part I: Continuous Exposure
- 1 May 1960
- journal article
- Published by Oxford University Press (OUP) in The British Journal of Radiology
- Vol. 33 (389), 287-301
- https://doi.org/10.1259/0007-1285-33-389-287
Abstract
A study has been made of the changes in the blood and bone marrow of rats subjected to continuous irradiation from a 137Cs source at dose-rates from 16 rads/day to 415 rads/day. At dose-rates of 84 rads/day and below there is a recovery in platelets and white cells after an initial fall. This recovery commences at about 20 days after the start of irradiation and at 84 rads/day is only transient. At 50 rads/day and below, however, near normal levels of blood count are maintained for a long period of time. Splenectomy profoundly affects the pattern of change, particularly with respect to the platelet level and the level of mononuclear leukocytes. Possible mechanisms for the maintenance of a steady state under continuous irradiation are discussed in relation to similar findings in the response of the intestinal epithelium.This publication has 5 references indexed in Scilit:
- II. Adaptation to Continuous Irradiation: Observations on the Rat IntestineThe British Journal of Radiology, 1959
- Certain Structural Aspects of Lymphocytes and Monocytes in Relation to the Clinical Condition of Persons Exposed to Ionizing RadiationThe British Journal of Radiology, 1959
- Response of Megakaryocytes of the ‘August’ Rat to X-irradiationInternational Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine, 1959
- Quantitative Studies on the Depletion of the Erythropoietic Cells in the Bone Marrow of the Irradiated RatBritish Journal of Haematology, 1957
- Anaemia and Erythropoiesis in the Irradiated Rat: an Experimental Study with Particular Reference to Techniques involving Radioactive IronBritish Journal of Haematology, 1955