A randomized, controlled pilot trial of hormone therapy for menopausal insomnia
- 13 October 2011
- journal article
- research article
- Published by Springer Science and Business Media LLC in Archives of Women's Mental Health
- Vol. 14 (6), 505-508
- https://doi.org/10.1007/s00737-011-0242-2
Abstract
Insomnia is a frequent climacteric symptom. This pilot, double-blind, randomized placebo-controlled trial compared estradiol associated with trimegestone or placebo in 12 women with perimenopausal insomnia. The Pittsburgh Sleep Quality Index (PSQI) was administered, and polysomnography was performed at baseline and after 28 days. Sleep efficiency and median score of the PSQI improved significantly in the hormone therapy group (HT) (p = 0.041 and p = 0.027, respectively) and not in placebo group. Perimenopausal insomnia improved after short-term HT.Keywords
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