Antimicrobial Resistance and Clinical Outcome of Bacteroides Bacteremia: Findings of a Multicenter Prospective Observational Trial
Open Access
- 1 June 2000
- journal article
- research article
- Published by Oxford University Press (OUP) in Clinical Infectious Diseases
- Vol. 30 (6), 870-876
- https://doi.org/10.1086/313805
Abstract
There is debate regarding the correlation between in vitro susceptibility testing and clinical response to therapy for bacteroides bacteremia. We conducted a prospective multicenter observational study of 128 patients with bacteroides bacteremia. Outcome was correlated with results of in vitro susceptibility testing of Bacteroides isolates recovered from blood and/or nonblood sites, determined with use of 3 end points: mortality at 30 days, clinical response (cure vs. failure), and microbiological response (eradication vs. persistence). The mortality rate among patients who received inactive therapy (45%) was higher than among patients who received active therapy (16%; P = .04). Clinical failure (82%) and microbiological persistence (42%) were higher for patients who received inactive therapy than for patients who received active therapy (22% and 12%, respectively; P = .0002 and .06, respectively). In vitro activity of agents directed at Bacteroides species reliably predicts outcome: the specificity was 97%, and positive predictive value was 82%. Antimicrobial susceptibility testing may be indicated for patients whose blood specimens yield Bacteroides species.Keywords
This publication has 11 references indexed in Scilit:
- Multicenter Study of In Vitro Susceptibility of the Bacteroides fragilis Group, 1995 to 1996, with Comparison of Resistance Trends from 1990 to 1996Antimicrobial Agents and Chemotherapy, 1999
- Antimicrobial Resistance in AnaerobesClinical Infectious Diseases, 1997
- Present Status of Therapy for Anaerobic InfectionsClinical Infectious Diseases, 1996
- Analysis of Trends in Antimicrobial Resistance Patterns Among Clinical Isolates of Bacteroides fragilis Group Species from 1990 to 1994Clinical Infectious Diseases, 1996
- Therapeutic Approaches in Patients With CandidemiaArchives of Internal Medicine, 1995
- Variation in the Susceptibility of Bacteroides fragilis Group Isolates from Six Chicago HospitalsClinical Infectious Diseases, 1993
- Correlation of various in vitro testing methods with clinical outcomes in patients with Bacteroides fragilis group infections treated with cefoxitin: a retrospective analysisAntimicrobial Agents and Chemotherapy, 1992
- Effect of beta-lactamase inhibitors on the activities of various beta-lactam agents against anaerobic bacteriaAntimicrobial Agents and Chemotherapy, 1991
- Epidemiology, Antimicrobial Susceptibility, Pathogenicity, and Significance of Bacteroides fragilis Group Organis,s Isolated at Los Angeles County-University of Southern California Medical CenterClinical Infectious Diseases, 1990
- Susceptibility of the Bacteroides fragilis group in the United States: analysis by site of isolationAntimicrobial Agents and Chemotherapy, 1988