G1 to S phase cell cycle transition in somatic and embryonic stem cells
- 8 July 2008
- journal article
- review article
- Published by Wiley in Journal of Anatomy
- Vol. 213 (1), 30-44
- https://doi.org/10.1111/j.1469-7580.2008.00931.x
Abstract
It is well known that G1 to S phase transition is tightly regulated by the expression and phosphorylation of a number of well-characterized cyclins, cyclin-dependent kinases and members of the retinoblastoma gene family. In this review we discuss the role of these components in regulation of G1 to S phase transition in somatic cells and human embryonic stem cells. Most importantly, we discuss some new tenable links between maintenance of pluripotency and cell cycle regulation in embryonic stem cells by describing the role that master transcription factors play in this process. Finally, the differences in cell cycle regulation between murine and human embryonic stem cells are highlighted, raising interesting questions regarding their biology and stages of embryonic development from which they have been derived.This publication has 124 references indexed in Scilit:
- Transcriptional activation of the histone nuclear factor P (HiNF-P) gene by HiNF-P and its cyclin E/CDK2 responsive co-factor p220NPAT defines a novel autoregulatory loop at the G1/S phase transitionGene, 2007
- Cdk1 is sufficient to drive the mammalian cell cycleNature, 2007
- Checkpoint-apoptosis uncoupling in human and mouse embryonic stem cells: a source of karyotpic instabilityBlood, 2007
- Nanog and transcriptional networks in embryonic stem cell pluripotencyCell Research, 2007
- Core Transcriptional Regulatory Circuitry in Human Embryonic Stem CellsCell, 2005
- Self-renewal of teratocarcinoma and embryonic stem cellsOncogene, 2004
- Culture and Characterization of Human Embryonic Stem CellsStem Cells and Development, 2004
- Development of mice expressing a single D-type cyclinPublished by Cold Spring Harbor Laboratory ,2002
- Cancer Cell CyclesScience, 1996
- Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesisNature, 1992