Transforming growth factor beta 1 suppresses acute and chronic arthritis in experimental animals.
Open Access
- 1 March 1991
- journal article
- Published by American Society for Clinical Investigation in JCI Insight
- Vol. 87 (3), 1108-1113
- https://doi.org/10.1172/jci115073
Abstract
Systemic administration of the cytokine, TGF beta 1, profoundly antagonized the development of polyarthritis in susceptible rats. TGF beta 1 administration (1 or 5 micrograms/animal), initiated one day before an arthritogenic dose of streptococcal cell wall (SCW) fragments, virtually eliminated the joint swelling and distortion typically observed during both the acute phase (articular index, AI = 2.5 vs. 11; P less than 0.025) and the chronic phase (AI = 0 vs. 12.5) of the disease. Moreover, TGF beta 1 suppressed the evolution of arthritis even when administration was begun after the acute phase of the disease. Histopathological examination of the joint revealed the systemic TGF beta 1 treatment greatly reduced inflammatory cell infiltration, pannus formation, and joint erosion. Consistent with the inhibition of inflammatory cell recruitment into the synovium, TGF beta 1 reversed the leukocytosis associated with the chronic phase of the arthritis. Control animals subjected to the same TGF beta 1 dosing regimen displayed no discernable immunosuppressive or toxic effects even after 4 wk of treatment. These observations not only provide insight into the immunoregulatory effects of TGF beta, but also implicate this cytokine as a potentially important therapeutic agent.Keywords
This publication has 32 references indexed in Scilit:
- Inflammatory and immunomodulatory roles of TGF-βImmunology Today, 1989
- Endothelial Adhesiveness for Blood Neutrophils Is Inhibited by Transforming Growth Factor-βScience, 1988
- Bacterial cell wall-induced immunosuppression. Role of transforming growth factor beta.The Journal of Experimental Medicine, 1988
- Transforming growth factor beta 1 selectively regulates early murine hematopoietic progenitors and inhibits the growth of IL-3-dependent myeloid leukemia cell lines.The Journal of Experimental Medicine, 1988
- Two forms of transforming growth factor-β distinguished by multipotential haematopoietic progenitor cellsNature, 1987
- Distribution and modulation of the cellular receptor for transforming growth factor-beta.The Journal of cell biology, 1987
- Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth.The Journal of Experimental Medicine, 1986
- Role of the thymus in streptococcal cell wall-induced arthritis and hepatic granuloma formation. Comparative studies of pathology and cell wall distribution in athymic and euthymic rats.JCI Insight, 1985
- The pathogenesis of group a streptococcal cell wall‐induced polyarthritis in the rat comparative studies in arthritis resistant and susceptible inbred rat strainsArthritis & Rheumatism, 1983
- Arthritis in rats after systemic injection of streptococcal cells or cell walls.The Journal of Experimental Medicine, 1977