Polypharmacy as a risk for fall occurrence in geriatric outpatients
- 23 December 2011
- journal article
- Published by Wiley in Geriatrics & Gerontology International
- Vol. 12 (3), 425-430
- https://doi.org/10.1111/j.1447-0594.2011.00783.x
Abstract
Objective: To investigate the predictors of falls, such as comorbidity and medication, in geriatric outpatients in a longitudinal observational study. Methods: A total of 172 outpatients (45 men and 126 women, mean age 76.9 ± 7.0 years) were evaluated. Physical examination, clinical history and medication profile were obtained from each patient at baseline. These patients were followed for up to 2 years and falls were self-reported to their physicians. The factors associated with falls were analyzed statistically. Results: A total of 32 patients experienced falls within 2 years. On univariate analysis, older age, osteoporosis, number of comorbid conditions and number of drugs were significantly associated with falls within 2 years. On multiple logistic regression analysis, the number of drugs was associated with falls, independent of age, sex, number of comorbid conditions and other factors that were significantly associated in univariate analysis. A receiver–operator curve evaluating the optimal cut-off value for the number of drugs showed that taking five or more drugs was a significant risk. Conclusion: In geriatric outpatients, polypharmacy is associated with falls. Intervention studies are needed to clarify the causal relationship between polypharmacy, comorbidity and falls. Geriatr Gerontol Int 2012; 12: 425–430.Keywords
This publication has 22 references indexed in Scilit:
- Association of polypharmacy with fall risk among geriatric outpatientsGeriatrics & Gerontology International, 2011
- Diabetes Medications Related to an Increased Risk of Falls and Fall-Related Morbidity in the ElderlyAnnals of Pharmacotherapy, 2010
- Diabetes mellitus and geriatric syndromesGeriatrics & Gerontology International, 2009
- Falls among community‐dwelling elderly people of Hokkaido, JapanGeriatrics & Gerontology International, 2008
- Simple screening test for risk of falls in the elderlyGeriatrics & Gerontology International, 2006
- Development of a portable fall risk index for elderly people living in the communityNippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics, 2005
- Risk Indicators for Falls in Institutionalized Frail ElderlyAmerican Journal of Epidemiology, 2003
- A Classification Tree for Predicting Recurrent Falling in Community‐Dwelling Older PersonsJournal of the American Geriatrics Society, 2003
- Dementia as a Risk Factor for Falls and Fall Injuries Among Nursing Home ResidentsJournal of the American Geriatrics Society, 2003
- Drugs and Falls in Older People: A Systematic Review and Meta‐analysis: II. Cardiac and Analgesic DrugsJournal of the American Geriatrics Society, 1999