Acute Cerebral Ischaemia: Concurrent Changes in Cerebral Blood Flow, Energy Metabolites, pH, and Lactate Measured with Hydrogen Clearance and31P and1H Nuclear Magnetic Resonance Spectroscopy. II. Changes during Ischaemia
- 1 August 1987
- journal article
- Published by SAGE Publications in Journal of Cerebral Blood Flow & Metabolism
- Vol. 7 (4), 394-402
- https://doi.org/10.1038/jcbfm.1987.82
Abstract
CBF has been measured with the hydrogen clearance technique in the two cerebral hemispheres of the gerbil under halothane anaesthesia. This has been correlated with changes in local pH, tissue lactate, and phosphorus energy metabolites measured in the same animals with1H and31P nuclear magnetic resonance spectroscopy. We demonstrate a threshold flow value for the metabolic changes associated with energy failure at a level similar to the values previously reported for electrical failure and tissue water accumulation, but higher than that associated with breakdown of extracellular potassium homeostasis.Keywords
This publication has 29 references indexed in Scilit:
- Neurometabolic effects of an inborn error of amino acid metabolism demonstratedin vivo by1H NMRMagnetic Resonance in Medicine, 1986
- Observation of a second phosphate pool in the perfused heart by 31P NMR; is this the mitochondrial phosphate?Journal of Molecular and Cellular Cardiology, 1983
- Whole Organ Metabolism Studied by NMRAnnual Review of Biophysics and Bioengineering, 1983
- A31P Nuclear Magnetic Resonancein vivoStudy of Cerebral Ischaemia in the GerbilJournal of Cerebral Blood Flow & Metabolism, 1982
- Temporal profile of neuronal damage in a model of transient forebrain ischemiaAnnals of Neurology, 1982
- 31P NMR saturation transfer measurements of the steady state rates of creatine kinase and ATP synthetase in the rat brainFEBS Letters, 1982
- Cerebral blood flow and edema following carotid occlusion in the gerbil.Stroke, 1980
- Clinical relevance of models of cerebral ischemia.Stroke, 1979
- Ischemic brain edema following middle cerebral artery occlusion in baboons: relationship between regional cerebral water content and blood flow at 1 to 2 hours.Stroke, 1979
- Cortical evoked potential and extracellular K+ and H+ at critical levels of brain ischemia.Stroke, 1977