Diffuse Spine Involvement in Sarcoidosis With Sternal Lytic Lesions
- 1 September 2007
- journal article
- case report
- Published by Ovid Technologies (Wolters Kluwer Health) in Spine
- Vol. 32 (20), E594-E597
- https://doi.org/10.1097/brs.0b013e31814b86d5
Abstract
Case report. To report 2 cases of sarcoidosis with a diffuse vertebral involvement, associated with a rare location in the sternum. Sarcoidosis is a systemic disease of unknown cause with various clinical and radiologic manifestations. Bone involvement is rare (1%–13% of cases). Vertebral involvement is very uncommon. Lytic lesions, sclerotic lesions, or both of these patterns may be observed. One patient complained of diffuse bone pain; the second patient was asymptomatic. Each patient had radiograph, CT, and MRI of the spine. The second patient also underwent a PET/CT FDG-(18F). Sternal bone biopsy was performed in both patients. Pathologic findings indicated typical pattern of bone sarcoidosis. Clinical and biologic improvement was noticed after treatment with corticosteroids. In our 2 cases, radiograph, CT, MRI, and PET/CT findings were evocative of diffuse spine involvement in sarcoidosis associated with sternal lytic lesions. This suspicion was confirmed by histopathologic findings, which found a typical pattern of sarcoidosis. These 2 cases emphasize the value of CT, MRI, and FDG-(18F) PET/CT for the diagnosis of diffuse spinal involvement in sarcoidosis and describe an exceptional association with sternal lytic lesions.Keywords
This publication has 17 references indexed in Scilit:
- Vertebral and Spinal Cord SarcoidosisAmerican Journal of Roentgenology, 2005
- Sarcoidosis Presenting as Metastatic Bony DiseaseRespiration, 2004
- FDG Positron Emission Tomography of Bone Involvement in SarcoidosisAmerican Journal of Roentgenology, 2004
- Radiologic Manifestations of Sarcoidosis in Various OrgansRadioGraphics, 2004
- Vertebral sarcoidosis: imaging findingsEuropean Radiology, 2000
- Sclerotic lesions of the cervical spine in sarcoidosis.Skeletal Radiology, 1998
- MRI of Vertebral SarcoidosisJournal of Computer Assisted Tomography, 1993
- Radioisotope Bone Scanning in a Case of SarcoidosisClinical Nuclear Medicine, 1985
- Radiographic, angiographic and radionuclide manifestations of osseous sarcoidosisRadioGraphics, 1983
- Bone and joint sarcoidosisSeminars in Arthritis and Rheumatism, 1976