LINC01287 regulates tumorigenesis and invasion via miR‐298/MYB in hepatocellular carcinoma
Open Access
- 22 August 2018
- journal article
- research article
- Published by Wiley in Journal of Cellular and Molecular Medicine
- Vol. 22 (11), 5477-5485
- https://doi.org/10.1111/jcmm.13818
Abstract
Recently, it was reported that long non‐coding RNAs (lncRNAs) participated in promoting hepatocellular carcinoma (HCC) initiation and progression. Herein, we reported that the expression level of LINC01287 was elevated in HCC cell lines and tissues. LINC01287 down‐regulation inhibited HCC cells growth and invasion both in vitro and in vivo. LINC01287 exerted as a ceRNA and negatively regulated miR‐298 expression. MYB was identified as a downstream target of miR‐298. The miR‐298/MYB axis mediated LINC01287's effect on HCC. To the best of our knowledge, our findings provided the first evidence that LINC01287 functioned as an oncogene in HCC. LINC01287 may be a candidate prognostic biomarker and a target for new therapies in HCC patients.Keywords
This publication has 24 references indexed in Scilit:
- Single-cell analysis of long non-coding RNAs in the developing human neocortexGenome Biology, 2016
- MiR-137 inhibits proliferation and angiogenesis of human glioblastoma cells by targeting EZH2Journal of Neuro-Oncology, 2015
- Long non-coding RNA CCAT1 promotes gallbladder cancer development via negative modulation of miRNA-218-5pCell Death & Disease, 2015
- SRF expedites metastasis and modulates the epithelial to mesenchymal transition by regulating miR-199a-5p expression in human gastric cancerCell Death & Differentiation, 2014
- A Long Noncoding RNA Activated by TGF-β Promotes the Invasion-Metastasis Cascade in Hepatocellular CarcinomaCancer Cell, 2014
- SnapShot: Hepatocellular CarcinomaCancer Cell, 2014
- MicroRNA-424 Is Down-Regulated in Hepatocellular Carcinoma and Suppresses Cell Migration and Invasion through c-MybPLOS ONE, 2014
- A case of small hepatocellular carcinoma with an extensive lymph node metastasis at diagnosisClinical and Molecular Hepatology, 2014
- miR-124 radiosensitizes human glioma cells by targeting CDK4Journal of Neuro-Oncology, 2013
- Long noncoding RNAs and the genetics of cancerBritish Journal of Cancer, 2013