Rapid generation of protein aerosols and nanoparticles via surface acoustic wave atomization
- 8 October 2008
- journal article
- Published by IOP Publishing in Nanotechnology
- Vol. 19 (45), 455103
- https://doi.org/10.1088/0957-4484/19/45/455103
Abstract
We describe the fabrication of a surface acoustic wave (SAW) atomizer and show its ability to generate monodisperse aerosols and particles for drug delivery applications. In particular, we demonstrate the generation of insulin liquid aerosols for pulmonary delivery and solid protein nanoparticles for transdermal and gastrointestinal delivery routes using 20 MHz SAW devices. Insulin droplets around 3 µm were obtained, matching the optimum range for maximizing absorption in the alveolar region. A new approach is provided to explain these atomized droplet diameters by returning to fundamental physical analysis and considering viscous-capillary and inertial-capillary force balance rather than employing modifications to the Kelvin equation under the assumption of parametric forcing that has been extended to these frequencies in past investigations. In addition, we consider possible mechanisms by which the droplet ejections take place with the aid of high-speed flow visualization. Finally, we show that nanoscale protein particles (50-100 nm in diameter) were obtained through an evaporative process of the initial aerosol, the final size of which could be controlled merely by modifying the initial protein concentration. These results illustrate the feasibility of using SAW as a novel method for rapidly producing particles and droplets with a controlled and narrow size distribution.This publication has 27 references indexed in Scilit:
- Evaporative self-assembly assisted synthesis of polymeric nanoparticles by surface acoustic wave atomizationNanotechnology, 2008
- A scaffold cell seeding method driven by surface acoustic wavesBiomaterials, 2007
- AC electrospray biomaterials synthesisBiomaterials, 2005
- Acoustic manipulation of small dropletsAnalytical and Bioanalytical Chemistry, 2004
- Microfabricated needles for transdermal delivery of macromolecules and nanoparticles: Fabrication methods and transport studiesProceedings of the National Academy of Sciences of the United States of America, 2003
- Fundamentals of pulmonary drug deliveryRespiratory Medicine, 2003
- Surface Acoustic Wave Devices in TelecommunicationsPublished by Springer Science and Business Media LLC ,2000
- Inhaled insulinAdvanced Drug Delivery Reviews, 1999
- Study on SAW Streaming and its Application to Fluid DevicesJapanese Journal of Applied Physics, 1990
- DIRECT PIEZOELECTRIC COUPLING TO SURFACE ELASTIC WAVESApplied Physics Letters, 1965