A self-splicing intron in the small subunit rRNA gene ofPneumocystis carinii
- 1 January 1989
- journal article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 17 (13), 5349-5360
- https://doi.org/10.1093/nar/17.13.5349
Abstract
The coding region for the Pneumocystis carinii small subunit rRNA (16S-like rRNA) contains 390 extra base pairs in a region that is highly conserved in other eukaryotic rRNA genes. The sequence has all the elements characteristic of group I self-splicing introns and interrupts the phylogenetically conserved helix proximal to the 3' terminus of the 16S-like rRNA. In vitro transcripts containing the putative group I intron were capable of undergoing a "self-splicing" reaction which required the presence of guanine nucleotide.Keywords
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