TESTICULAR MICROLITHIASIS AND ANTISPERM ANTIBODIES FOLLOWING TESTICULAR BIOPSY IN BOYS WITH CRYPTORCHIDISM
- 1 November 2005
- journal article
- Published by Ovid Technologies (Wolters Kluwer Health) in Journal of Urology
- Vol. 174 (5), 2008-2010
- https://doi.org/10.1097/01.ju.0000176480.93985.37
Abstract
Purpose: Testicular biopsy (TBx) performed during orchiopexy in boys with cryptorchidism can help to predict future semen analyses and possibly identify patients at risk for testicular cancer. It has been theorized that TBx can be detrimental to the long-term health of the testis. We examined testicular microlithiasis (TM) and antisperm antibody (ASA) production in cryptorchid TBx. Materials and Methods: A total of 112 males underwent fertility evaluation. These patients had previously undergone orchiopexy and bilateral TBx (mean age 8.6 years) for unilateral or bilateral undescended testis. At a mean age of 19.6 years all patients underwent physical examination and scrotal ultrasound for evaluation of testis size, echotexture and abnormalities. Of 112 patients 57 also underwent direct Immunobead® assay with positive controls. Moving sperm free and/or bound to IgG bead complex were counted in the preparation. Results: A total of 29 patients had bilateral and 83 had unilateral undescended testis. Of the 112 patients 26 were black and 86 were white. Four black patients (15.4%) and 4 white patients (4.7%) had testicular microlithiasis. Three patients had bilateral and 5 had unilateral diffuse TM. No tunica albuginea scars or testis masses were noted. In the 57 patients who underwent direct Immunobead assay no semen sample demonstrated evidence of forming bead-sperm complex, ie none had direct ASA. Conclusions: No patient exhibited evidence of direct ASA. Prepubertal open TBx does not increase the rate of TM. We found no evidence of additive testicular damage associated with TBx at the time of orchiopexy.Keywords
This publication has 19 references indexed in Scilit:
- Testis Histopathology in Boys With Cryptorchidism Correlates With Future Fertility PotentialJournal of Urology, 2003
- Ultrasound, antisperm antibody, and hormone profiles after testicular Trucut biopsyFertility and Sterility, 2001
- Microcalcifications and carcinoma in situ of the testisBJU International, 2001
- COMPARATIVE ASSESSMENT OF PEDIATRIC TESTICULAR VOLUME: ORCHIDOMETER VERSUS ULTRASOUNDJournal of Urology, 2000
- Treatment With a Luteinizing Hormone-Releasing Hormone Analogue after Successful Orchiopexy Markedly Improves the Change of Fertility Later in LifeJournal of Urology, 1997
- Risk of testicular cancer in cohort of boys with cryptorchidismBMJ, 1997
- Fertility Potential After Unilateral Orchiopexy: Simultaneous Testicular Biopsy and Orchiopexy in a Cohort of 87 PatientsJournal of Urology, 1996
- The Impact of Antisperm Antibodies on Human InfertilityJournal of Urology, 1987
- Fertility in cryptorchidismEuropean Journal of Pediatrics, 1987
- Cryptorchidism and Malignant Testicular DiseasePublished by Springer Science and Business Media LLC ,1983