TUCAN/CARDINAL and DRAL participate in a common pathway for modulation of NF‐κB activation
- 30 May 2002
- journal article
- Published by Wiley in FEBS Letters
- Vol. 521 (1-3), 165-169
- https://doi.org/10.1016/s0014-5793(02)02869-7
Abstract
Proteins containing the caspase recruiting domain (CARD) have emerged as critical regulators of different signal transduction pathways, including those controlling apoptosis and activation of necrosis factor (NF)-κB transcription factor. TUCAN/CARDINAL is a recently identified CARD-containing protein involved in regulation of caspases and NF-κB activation. We find that TUCAN/CARDINAL associates with DRAL, a p53-responsive gene implicated in induction of apoptosis. We also show that, whereas TUCAN/CARDINAL exerts a suppressive effect on NF-κB activity, expression of DRAL results in enhancement of NF-κB activation. Thus, our observations suggest that DRAL and TUCAN/CARDINAL may participate in a regulatory mechanism that coordinates cellular responses controlled by NF-κB transcription factorKeywords
This publication has 17 references indexed in Scilit:
- TUCAN, an Antiapoptotic Caspase-associated Recruitment Domain Family Protein Overexpressed in CancerPublished by Elsevier BV ,2001
- Nod2, a Nod1/Apaf-1 Family Member That Is Restricted to Monocytes and Activates NF-κBJournal of Biological Chemistry, 2001
- c-E10 Is a Caspase-recruiting Domain-containing Protein That Interacts with Components of Death Receptors Signaling Pathway and Activates Nuclear Factor-κBJournal of Biological Chemistry, 1999
- CLAP, a Novel Caspase Recruitment Domain-containing Protein in the Tumor Necrosis Factor Receptor Pathway, Regulates NF-κB Activation and ApoptosisPublished by Elsevier BV ,1999
- Human CARD4 Protein Is a Novel CED-4/Apaf-1 Cell Death Family Member That Activates NF-κBJournal of Biological Chemistry, 1999
- Nod1, an Apaf-1-like Activator of Caspase-9 and Nuclear Factor-κBPublished by Elsevier BV ,1999
- CIPER, a Novel NF κB-activating Protein Containing a Caspase Recruitment Domain with Homology to Herpesvirus-2 Protein E10Published by Elsevier BV ,1999
- Death Receptors: Signaling and ModulationScience, 1998
- The CARD domain: a new apoptotic signalling motifTrends in Biochemical Sciences, 1997
- Apoptosis in the Pathogenesis and Treatment of DiseaseScience, 1995