Plasmin therapy enhances mobilization of HPCs after G-CSF
- 15 November 2008
- journal article
- clinical trial
- Published by American Society of Hematology in Blood
- Vol. 112 (10), 4048-4050
- https://doi.org/10.1182/blood-2008-07-166587
Abstract
The role of proteinases in the mobilization of hematopoietic progenitor cells (HPCs) after granulocyte colony-stimulating factor (G-CSF) remains unclear. Here we report that genetic loss of the plasminogen activator inhibitor Pai-1 or of the plasmin inhibitor α2-antiplasmin increases HPC mobilization in response to G-CSF. Moreover, thrombolytic agents, such as tenecteplase and microplasmin, enhance HPC mobilization in mice and humans. Taken together, these findings identify a novel role for plasmin in augmenting HPC mobilization in response to G-CSF.Keywords
This publication has 18 references indexed in Scilit:
- The Plasminogen Fibrinolytic Pathway Is Required for Hematopoietic RegenerationCell Stem Cell, 2007
- Serine protease inhibitors serpina1 and serpina3 are down-regulated in bone marrow during hematopoietic progenitor mobilizationThe Journal of Experimental Medicine, 2005
- Increased circulating hematopoietic and endothelial progenitor cells in the early phase of acute myocardial infarctionBlood, 2005
- Comparative effects of microplasmin and tissue‐type plasminogen activator (tPA) on cerebral hemorrhage in a middle cerebral artery occlusion model in miceJournal of Thrombosis and Haemostasis, 2004
- Characterization of hematopoietic progenitor mobilization in protease-deficient miceBlood, 2004
- Use of Matrix Metalloproteinase (MMP)‐9 Knockout Mice Demonstrates that MMP‐9 Activity Is not Absolutely Required for G‐CSF or Flt‐3 Ligand‐Induced Hematopoietic Progenitor Cell Mobilization or EngraftmentThe International Journal of Cell Cloning, 2003
- Stem Cell MobilizationHematology-American Society Hematology Education Program, 2003
- G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4Nature Immunology, 2002
- Characterization of the murine plasminogen/urokinase‐type plasminogen‐activator systemEuropean Journal of Biochemistry, 1996
- Characterization of the Murine Plasma Fibrinolytic SystemEuropean Journal of Biochemistry, 1994