Rannasangpei Is a Therapeutic Agent in the Treatment of Vascular Dementia
Open Access
- 1 January 2016
- journal article
- research article
- Published by Hindawi Limited in Evidence-Based Complementary and Alternative Medicine
- Vol. 2016, 1-10
- https://doi.org/10.1155/2016/2530105
Abstract
Rannasangpei (RSNP) is used as a therapeutic agent in the treatment of cardiovascular diseases, neurological disorders, and neurodegeneration in China; however, its potential use in the treatment of vascular dementia (VD) was unclear. In this study, our aim was to examine the neuroprotective effect of RSNP in a VD rat model, which was induced by permanent bilateral common carotid artery occlusion (2VO). Four-week administration with two doses of RSNP was investigated in our study. Severe cognitive deficit in the VD model, which was confirmed in Morris water maze (MWM) test, was significantly restored by the administration of RSNP. ELISA revealed that the treatments with both doses of RSNP could reinstate the cholinergic activity in the VD animals by elevating the production of choline acetyltransferase (ChAT) and reducing the acetylcholinesterase (AChE); the treatment of RSNP could also reboot the level of superoxide dismutase (SOD) and decrease malondialdehyde (MDA). Moreover, Western blot and quantitative PCR (Q-PCR) results indicated that the RSNP could suppress the apoptosis in the hippocampus of the VD animals by increasing the expression ratio of B-cell lymphoma-2 (Bcl-2) to Bcl-2-associated X protein (Bax). These results suggested that RSNP might be a therapeutic agent in the treatment of vascular dementia in the future.Keywords
Funding Information
- National Special Financial Foundation in China (1981420400011)
This publication has 33 references indexed in Scilit:
- Characterization of Tibetan MedicineZuotaby Multiple TechniquesBioinorganic Chemistry and Applications, 2013
- Tibetan Medicine: A Systematic Review of the Clinical Research Available in the WestEvidence-Based Complementary and Alternative Medicine, 2013
- The cholinergic system and spatial learningBehavioural Brain Research, 2011
- Alleviating neuropsychiatric symptoms in dementia: the effects of Ginkgo biloba extract EGb 761®. Findings from a randomized controlled trialNeuropsychiatric Disease and Treatment, 2011
- Alzheimer's disease and vascular dementia in developing countries: prevalence, management, and risk factorsThe Lancet Neurology, 2008
- l-3-n-Butylphthalide Improves Cognitive Impairment Induced by Chronic Cerebral Hypoperfusion in RatsThe Journal of pharmacology and experimental therapeutics, 2007
- Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT MethodMethods, 2001
- Role of Oxidants in Ischemic Brain DamageStroke, 1996
- Effect of transient cerebral ischaemia on acetylcholine release in the gerbil hippocampusNeuroReport, 1994
- Free radical damage to protein and DNA: Mechanisms involved and relevant observations on brain undergoing oxidative stressAnnals of Neurology, 1992