Tumor budding cells, cancer stem cells and epithelial-mesenchymal transition-type cells in pancreatic cancer
Open Access
- 1 January 2013
- journal article
- Published by Frontiers Media SA in Frontiers in Oncology
- Vol. 2, 209
- https://doi.org/10.3389/fonc.2012.00209
Abstract
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers with a 5-year survival rate of less than 5%. Moreover, PDAC escapes early detection and resists treatment. Multiple combinations of genetic alterations are known to occur in PDAC including mutational activation of KRAS, inactivation of p16/CDKN2A and SMAD4 (DPC4) and dysregulation of PTEN/PI3K/AKT signaling. Through their interaction with Wingless-INT pathway, the downstream molecules of these pathways have been implicated in the promotion of epithelial–mesenchymal transition (EMT). Emerging evidence has demonstrated that cancer stem cells (CSCs), small populations of which have been identified in PDAC, and EMT-type cells play critical roles in drug resistance, invasion, and metastasis in pancreatic cancer. EMT may be histologically represented by the presence of tumor budding which is described as the occurrence of single tumor cells or small clusters (<5) of dedifferentiated cells at the invasive front of gastrointestinal (including colorectal, oesophageal, gastric, and ampullary) carcinomas and is linked to poor prognosis. Tumor budding has recently been shown to occur frequently in PDAC and to be associated with adverse clinicopathological features and decreased disease-free and overall survival. The aim of this review is to present a short overview on the morphological and molecular aspects that underline the relationship between tumor budding cells, CSCs, and EMT-type cells in PDAC.Keywords
This publication has 43 references indexed in Scilit:
- EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancerOncogene, 2010
- Pancreatic CancerThe New England Journal of Medicine, 2010
- Epithelial-Mesenchymal Transitions in Development and DiseaseCell, 2009
- Inflammation: A driving force speeds cancer metastasisCell Cycle, 2009
- The role of epithelial-mesenchymal transition in cancer pathologyPathology, 2007
- Regionalised signalling within the extraembryonic ectoderm regulates anterior visceral endoderm positioning in the mouse embryoMechanisms of Development, 2006
- The Snail genes as inducers of cell movement and survival: implications in development and cancerDevelopment, 2005
- Population Genetics of Neisseria gonorrhoeae in a High-Prevalence Community Using a Hypervariable Outer Membrane porB and 13 Slowly Evolving Housekeeping GenesMolecular Biology and Evolution, 2005
- Immunohistochemical Labeling for Dpc4 Mirrors Genetic Status in Pancreatic Adenocarcinomas: A New Marker of DPC4 InactivationThe American Journal of Pathology, 2000
- Prognostic value of tumor “budding” in patients with colorectal cancerDiseases of the Colon & Rectum, 1993