Plexiform angiomyxoid myofibroblastic tumor of the stomach
Open Access
- 1 January 2010
- journal article
- Published by Baishideng Publishing Group Inc. in World Journal of Gastroenterology
- Vol. 16 (23), 2835-2840
- https://doi.org/10.3748/wjg.v16.i23.2835
Abstract
Plexiform angiomyxoid myofibroblastic tumor of the stomach is a unique mesenchymal tumor that we first described in 2007. The tumor is very rare, and to date, only 18 cases confirmed by immunohistochemistry have been reported in the literature. The patients’ ages ranged from 7 to 75 years (mean, 43 years), and the male-to-female ratio was approximately 1:1. Representative clinical symptoms are ulceration, associated upper gastrointestinal bleeding (hematemesis), and anemia. The tumors are located at the antrum in all cases, and grossly, the tumor is whitish to brownish or reddish, and forms a lobulated submucosal or transmural mass. Microscopically, the tumor is characterized by a plexiform growth pattern, the proliferation of cytologically bland spindle cells, and a myxoid stroma that is rich in small vessels and positive for Alcian blue stain. Immunohistochemically, the tumor cells are positive for α-smooth muscle actin and negative for KIT and CD34. Differential diagnoses include gastrointestinal stromal tumor and other mesenchymal tumors of the gastrointestinal tract. Some authors proposed that this tumor should be designated as “plexiform fibromyxoma”, but this designation might cause confusion. The tumor is probably benign and thus far, neither recurrence nor metastasis has been reported.Keywords
This publication has 23 references indexed in Scilit:
- Plexiform FibromyxomaThe American Journal of Surgical Pathology, 2009
- Gastric fibromyxoma, a distinct entity of pure fibroblastic tumor – an ultrastructural studyAPMIS, 2004
- Gain-of-function mutations of platelet-derived growth factor receptor α gene in gastrointestinal stromal tumorsGastroenterology, 2003
- PDGFRA Activating Mutations in Gastrointestinal Stromal TumorsScience, 2003
- Efficacy and Safety of Imatinib Mesylate in Advanced Gastrointestinal Stromal TumorsNew England Journal of Medicine, 2002
- KIT activation is a ubiquitous feature of gastrointestinal stromal tumors.2001
- Expression of the Intermediate Filament Nestin in Gastrointestinal Stromal Tumors and Interstitial Cells of CajalThe American Journal of Pathology, 2001
- Gastrointestinal Stromal Tumors—Value of CD34 Antigen in their Identification and Separation from True Leiomyomas and SchwannomasThe American Journal of Surgical Pathology, 1995
- Inflammatory Myofibroblastic Tumor (plasma cell granuloma): Clinicopathologic Study of 20 Cases with Immunohistochemical and Ultrastructural ObservationsAmerican Journal of Clinical Pathology, 1990
- Ultratructure of Gastric Myxofibroma with Intracytoplasmic CollagenUltrastructural Pathology, 1982