Neurokinin 1‐receptors and sensory neuropeptides in tendon insertions at the medial and lateral epicondyles of the humerus Studies on tennis elbow and medial epicondylalgia
- 1 March 2004
- journal article
- Published by Wiley in Journal of Orthopaedic Research
- Vol. 22 (2), 321-327
- https://doi.org/10.1016/s0736-0266(03)00183-9
Abstract
There is no information on the sensory innervation at the flexor muscle origin at the medial epicondyle of the humerus and it is not known if substance P receptors (Neurokinin 1-receptors, NK1-R) are present in tendon insertions in general. In the present investigation, we have studied the muscle origin in patients suffering from medial epicondylalgia and tennis elbow. Immunohistochemistry and antibodies to substance P (SP) and CGRP as well as the general nerve marker PGP 9.5 were used. Specific immunoreactions were observed in nerve bundles and as free nerve fibers. The immunoreactive structures were partly seen in association with some of the blood vessels. The observations constitute a morphological correlate for the occurrence of nerve mediated effects in this region. By using immunohistochemistry and antibodies to NK1-R, the distribution of this receptor was studied at the insertion of the proximal tendon of the extensor carpi radialis brevis muscle at the lateral epicondyle. Specific immunoreactions were seen as varicose fibers occurring as single fibers or grouped into bundles, indicating that SP has effects in the nerves in this region. The results give further evidence for a possible neurogenic involvement in the pathophysiology of tennis elbow and in medial epicondylalgia.This publication has 49 references indexed in Scilit:
- Substance P (Neurokinin-1) and Neurokinin A (Neurokinin-2) Receptor Gene and Protein Expression in the Healthy and Inflamed Human IntestineThe American Journal of Pathology, 2000
- Immunohistochemical Demonstration of Sensory and Autonomic Nerve Terminals in Herniated Lumbar Disc TissueSpine, 1996
- Dexamethasone and activators of the protein kinase A and C signal transduction pathways regulate neuronal calcitonin gene-related peptide expression and releaseBrain Research, 1995
- Modulation of the release and activity of neuropeptides in the microcirculationCanadian Journal of Physiology and Pharmacology, 1995
- Acute joint inflammation—Mechanisms and mediatorsGeneral Pharmacology: The Vascular System, 1994
- Neuropeptides and interleukin-6 in human joint inflammation. Relationship between intraarticular substance P and interleukin-6 concentrationsNeuroscience Letters, 1994
- Physiologic consequences of surgical lengthening of extensor carpi radialis brevis muscle-tendon junction for tennis elbowThe Journal of Hand Surgery, 1994
- Calcitonin gene-related peptide, neurokinin A and substance P: Effects on Nociception and neurogenic inflammation in human skin and temporal musclePeptides, 1991
- Immunoreactive Neuropeptides in Nerves in Ligamentous TissueClinical Orthopaedics and Related Research, 1991
- Effect of nerve injury on fracture healing: Callus formation studied in the ratActa Orthopaedica, 1985