Osteosarcoma after allogeneic bone marrow transplantation. A report of four cases from the Cooperative Osteosarcoma Study Group (COSS)
Open Access
- 1 March 2003
- journal article
- research article
- Published by Springer Science and Business Media LLC in Bone Marrow Transplantation
- Vol. 31 (5), 353-359
- https://doi.org/10.1038/sj.bmt.1703864
Abstract
Osteosarcoma, one of the most frequent secondary malignancies after the treatment of young patients with cancer, has only very rarely been observed in association with hematopoietic stem cell transplantation (HSCT). We report four patients who were identified by searching the database of the Cooperative Osteosarcoma Study Group (COSS) for patients whose osteosarcoma arose following HSCT. Transplant indications had been acute lymphoblastic leukemia (3) and sickle cell disease (1), and the stem cell source was bone marrow in all cases (three allo-geneic, one syngeneic). All four had received chemotherapy with alkylators as part of their conditioning regimen and/or first line therapy. The conditioning regimen included total body irradiation in three patients. The osteosarcomas arose at the age (adolescence) and sites (around the knee) typical for the disease. All four patients received chemotherapy as part of multimodal osteosarcoma treatment, and all four are currently alive, three in continuous remission at 5 7/12, 2 11/12, and 0 6/12 years and one with relapsed osteosarcoma at 4 1/12 years. One of the osteosarcoma-free survivors suffered a third malignancy, myelodysplastic syndrome. Osteosarcoma should be included among the secondary malignancies that can arise following HSCT. Multi-modal therapy according to guidelines for de novo osteosarcoma can lead to long-term survival in selected patients.Keywords
This publication has 32 references indexed in Scilit:
- Co-operative study group for childhood acute lymphoblastic leukemia (COALL): long-term follow-up of trials 82, 85, 89 and 92Leukemia, 2000
- Long-term results of four consecutive trials in childhood ALL performed by the ALL-BFM study group from 1981 to 1995Leukemia, 2000
- Radiation-induced bone sarcoma following total body irradiation: role of additional radiation on localized areasBone Marrow Transplantation, 2000
- Treatment of solid tumors following allogeneic bone marrow transplantationBone Marrow Transplantation, 2000
- Neoadjuvante Therapie des lokalisierten Osteosarkoms der ExtremitätenKlinische Padiatrie, 1999
- Sarcoma arising in irradiated boneCancer, 1998
- Secondary breast cancer in patients presenting with osteosarcoma: Possible involvement of germline p53 mutationsMedical and Pediatric Oncology, 1994
- Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other NeoplasmsScience, 1990
- Bone Sarcomas Linked to Radiotherapy and Chemotherapy in ChildrenNew England Journal of Medicine, 1987
- Bone sarcoma as a second malignant neoplasm in children: Influence of radiation and genetic predispositionCancer, 1980