Cell Activation by Ligands of the Toll-Like Receptor and Interleukin-1 Receptor Family Depends on the Function of the Large-Conductance Potassium Channel MaxiK in Human Macrophages
- 1 July 2006
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 74 (7), 4354-4356
- https://doi.org/10.1128/iai.01783-05
Abstract
Performing patch-clamp experiments on human macrophages, we show that the K + channel MaxiK is activated by lipopolysaccharide, peptidoglycan, and interleukin-1. Cytokine production initiated by several Toll-like receptor (TLR) ligands and by interleukin-1 is inhibited by MaxiK blockade. This provides evidence for functional association of the MaxiK channel and TLR signaling complexes.Keywords
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