Carbonic Anhydrase in Dental Tissue and the Effects of Parathyroid Hormone and Fluoride on Its Activity
- 1 September 1961
- journal article
- research article
- Published by SAGE Publications in Journal of Dental Research
- Vol. 40 (5), 971-974
- https://doi.org/10.1177/00220345610400052301
Abstract
Carbonic anhydrase activity was demonstrated by manometric measurement in the incisors as well as in the femurs of rats, but not in human permanent teeth. Acetazolamide and sodium fluoride were about equipotent as inhibitors of dental carbonic anhydrase. They depressed dental carbonic anhydrase more intensely than alkaline phosphatase (determined spectrophotometrically). Para-thyroidectomy caused a significant decrease in alkaline phosphatase activity in the bone and showed a similar tendency, though statistically not significant, in the incisors. Administration of parathyroid extract increased the activity noticeably. The possible role played by both enzymes under the influence of the parathyroid gland in the calcification of the dental and bone tissues was discussed.This publication has 12 references indexed in Scilit:
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