Trained immunity: A program of innate immune memory in health and disease
Top Cited Papers
- 22 April 2016
- journal article
- review article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 352 (6284), aaf1098
- https://doi.org/10.1126/science.aaf1098
Abstract
The general view that only adaptive immunity can build immunological memory has recently been challenged. In organisms lacking adaptive immunity, as well as in mammals, the innate immune system can mount resistance to reinfection, a phenomenon termed “trained immunity” or “innate immune memory.” Trained immunity is orchestrated by epigenetic reprogramming, broadly defined as sustained changes in gene expression and cell physiology that do not involve permanent genetic changes such as mutations and recombination, which are essential for adaptive immunity. The discovery of trained immunity may open the door for novel vaccine approaches, new therapeutic strategies for the treatment of immune deficiency states, and modulation of exaggerated inflammation in autoinflammatory diseases.Keywords
Funding Information
- Netherlands Organization for Scientific Research
- European Research Council (ERC) Consolidator (310372)
- Deutsche Forschungsgemeinschaft
- Excellence Cluster Immunosensation
- Science Foundation Ireland (11/P1/1036)
This publication has 116 references indexed in Scilit:
- Dectin-1 plays a redundant role in the immunomodulatory activities of β-glucan-rich ligands in vivoMicrobes and Infection, 2013
- Bacille Calmette-Guérin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytesProceedings of the National Academy of Sciences of the United States of America, 2012
- Critical role for the chemokine receptor CXCR6 in NK cell–mediated antigen-specific memory of haptens and virusesNature Immunology, 2010
- The widespread regulation of microRNA biogenesis, function and decayNature Reviews Genetics, 2010
- Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell IdentitiesMolecular Cell, 2010
- The role of pattern-recognition receptors in innate immunity: update on Toll-like receptorsNature Immunology, 2010
- Identification and Characterization of Enhancers Controlling the Inflammatory Gene Expression Program in MacrophagesImmunity, 2010
- A Unifying Model for the Selective Regulation of Inducible Transcription by CpG Islands and Nucleosome RemodelingCell, 2009
- Inositol phosphatase SHIP1 is a primary target of miR-155Proceedings of the National Academy of Sciences of the United States of America, 2009
- Adaptive immune features of natural killer cellsNature, 2009