Glucose conjugation for the specific targeting and treatment of cancer
Top Cited Papers
- 8 April 2013
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Science
- Vol. 4 (6), 2319-2333
- https://doi.org/10.1039/c3sc22205e
Abstract
Cancers of diverse origins exhibit marked glucose avidity and high rates of aerobic glycolysis. Increased understanding of this dysfunctional metabolism known as the Warburg effect has led to an interest in targeting it for cancer therapy. One promising strategy for such targeting is glycoconjugation, the linking of a drug to glucose or another sugar. This review summarizes the most salient examples of glycoconjugates, in which known cytotoxins or anticancer therapeutics have been linked to glucose (or another glucose transporter substrate sugar) for improved cancer targeting and selectivity. Building on these examples, this review also provides a series of guidelines for the design and mechanistic evaluation of future glycoconjugates.Keywords
This publication has 100 references indexed in Scilit:
- Expression of GLUT1 and GLUT3 Glucose Transporters in Endometrial and Breast CancersPathology and Oncology Research, 2012
- Modulation of Glucose Transporter 1 (GLUT1) Expression Levels Alters Mouse Mammary Tumor Cell Growth In Vitro and In VivoPLOS ONE, 2011
- Prognostic and Predictive Role of Lactate Dehydrogenase 5 Expression in Colorectal Cancer Patients Treated with PTK787/ZK 222584 (Vatalanib) Antiangiogenic TherapyClinical Cancer Research, 2011
- Warfarin Glycosylation Invokes a Switch from Anticoagulant to Anticancer ActivityChemMedChem, 2011
- Hallmarks of Cancer: The Next GenerationCell, 2011
- Assessment of Chemoselective Neoglycosylation Methods Using Chlorambucil as a ModelJournal of Medicinal Chemistry, 2010
- Dynamic Near-Infrared Optical Imaging of 2-Deoxyglucose Uptake by Intracranial Glioma of Athymic MicePLOS ONE, 2009
- Model of the Exofacial Substrate-Binding Site and Helical Folding of the Human Glut1 Glucose Transporter Based on Scanning MutagenesisBiochemistry, 2009
- GLUT1 Expression Is Increased in Hepatocellular Carcinoma and Promotes TumorigenesisThe American Journal of Pathology, 2009
- On the Origin of Cancer CellsScience, 1956