Integrated equation to evaluate accumulation profiles of drugs eliminated by Michaelis-Menten kinetics
- 1 April 1979
- journal article
- research article
- Published by Springer Science and Business Media LLC in Journal of Pharmacokinetics and Biopharmaceutics
- Vol. 7 (2), 227-232
- https://doi.org/10.1007/bf01059740
Abstract
Using an equation for the calculation of plasma profiles of drug based on the zero-order input and Michaelis-Menten kinetic output in a one-compartment open model system, the times required to reach various degrees of several steady-state plasma concentrations of phenytoin are calculated. The effect of the apparent volume of distribution (due to intersubject variation or change in protein and/or tissue binding, etc.) on the time required to reach various fractions of steady-state plasma concentrations is discussed.Keywords
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