Genes that mediate breast cancer metastasis to lung
Top Cited Papers
- 28 July 2005
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 436 (7050), 518-524
- https://doi.org/10.1038/nature03799
Abstract
By means of in vivo selection, transcriptomic analysis, functional verification and clinical validation, here we identify a set of genes that marks and mediates breast cancer metastasis to the lungs. Some of these genes serve dual functions, providing growth advantages both in the primary tumour and in the lung microenvironment. Others contribute to aggressive growth selectively in the lung. Many encode extracellular proteins and are of previously unknown relevance to cancer metastasis.Keywords
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