Screening for IgE-Mediated Allergy
- 1 September 1980
- Vol. 35 (6), 491-501
- https://doi.org/10.1111/j.1398-9995.1980.tb01796.x
Abstract
Sera from 425 patients were analysed with Phadebas RAST reagents against a panel of 19 allergens and the most commonly positive results were to grass pollen, Dermatophagoides pteronyssinus and cat epithelium. Of the 275 sera RAST-positive to any allergen, 26l were positive by a RAST technique which used a mixture of the three most common U.K. allergens; the remainder were usually positive to a mould. We conclude that 1) when a positive result is obtained after screening by the mixed-allergen RAST and a representative mould RAST, then other positive RAST results are possible, but that the extent of the investigation can be guided by a knowledge of the total serum IgE level and a computer-based history analysis; 2) when the mixed-allergen RAST and a representative mould RAST is negative, then a more specified RAST including all 19 allergens used in this investigation will be negative; 3) a positive mixed-allergen RAST result is likely to be associated with a total serum IgE level over 40 U/ml and a positive symptom pattern score derived from the computer-based history analysis.Keywords
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