Respiratory Picornaviruses and Respiratory Syncytial Virus as Causative Agents of Acute Expiratory Wheezing in Children
Open Access
- 1 June 2004
- journal article
- Published by Centers for Disease Control and Prevention (CDC) in Emerging Infectious Diseases
- Vol. 10 (6), 1095-1101
- https://doi.org/10.3201/eid1006.030629
Abstract
We studied the viral etiology of acute expiratory wheezing (bronchiolitis, acute asthma) in 293 hospitalized children in a 2-year prospective study in Finland. A potential causative viral agent was detected in 88% of the cases. Eleven different viruses were represented. Respiratory syncytial virus (RSV) (27%), enteroviruses (25%), rhinovirus (24%), and nontypable rhino/enterovirus (16%) were found most frequently. In infants, RSV was found in 54% and respiratory picornaviruses (rhinovirus and enteroviruses) in 42% of the cases. In older children, respiratory picornaviruses dominated (65% of children ages 1-2 years and 82% of children ages >3 years). Human metapneumovirus was detected in 4% of all children and in 11% of infants. To prevent and treat acute expiratory wheezing illnesses in children, efforts should be focused on RSV, enterovirus, and rhinovirus infections.Keywords
This publication has 40 references indexed in Scilit:
- Rhinovirus-induced wheezing in infancy—the first sign of childhood asthma?Journal of Allergy and Clinical Immunology, 2003
- Diagnosis of Respiratory Syncytial Virus Infection: Comparison of Reverse Transcription-PCR to Viral Culture and Serology in Adults with Respiratory IllnessJournal of Clinical Microbiology, 2002
- Intranasal fluticasone propionate does not prevent acute otitis media during viral upper respiratory infection in childrenJournal of Allergy and Clinical Immunology, 2000
- Respiratory virus infections and aeroallergens in acute bronchial asthma.Archives of Disease in Childhood, 1984
- The etiologic and epidemiologic spectrum of bronchiolitis in pediatric practiceThe Journal of Pediatrics, 1979
- Respiratory viral infection and wheezy bronchitis in childhood.Thorax, 1979
- Viral infection in wheezy bronchitis and asthma in children.Archives of Disease in Childhood, 1976
- Respiratory viral infection in childhood. A survey in general practice, Roehampton 1967–1972Epidemiology and Infection, 1975
- Epidemiologic patterns of acute lower respiratory disease of children in a pediatric group practiceThe Journal of Pediatrics, 1971
- A Collaborative Study of the Aetiology of Acute Respiratory Infections in Britain 1961-4BMJ, 1965