Mislabeled units of umbilical cord blood detected by a quality assurance program at the transplantation center
- 20 August 2009
- journal article
- case report
- Published by American Society of Hematology in Blood
- Vol. 114 (8), 1684-1688
- https://doi.org/10.1182/blood-2009-02-205047
Abstract
We instituted procedures to check the identity of cord blood unit provided for transplantation by carrying out ABO and human leukocyte antigen (HLA) typing of the thawed units before transplantation. ABO typing is done using standard techniques. Rapid HLA class I serology is with monoclonal antibody trays (One Lambda Inc) using standard incubations. One mislabeled umbilical cord blood (UCB) unit was detected on the day of intended transplantation by repeat ABO typing of the thawed unit at our transplantation center. Because ABO typing will not detect all labeling errors, the rapid serologic class I HLA typing procedure was done on thawed units just before transplantation for all units without an attached segment. This procedure identified a second mislabeled unit. In a 6-year period, 2 of 871 (0.2%) cord blood units sent to us for transplantation were mislabeled and potentially would have been transplanted incorrectly. This error rate of 1 per 249 (0.4%) patients could have potentially devastating consequences.Keywords
This publication has 25 references indexed in Scilit:
- Outcomes of transplantation of unrelated donor umbilical cord blood and bone marrow in children with acute leukaemia: a comparison studyThe Lancet, 2007
- Donor selection for unrelated cord blood transplantsCurrent Opinion in Immunology, 2006
- Issues in the quality of umbilical cord blood stem cells for transplantationTransfusion, 2005
- The Cord-Blood-Bank ControversiesThe New England Journal of Medicine, 2004
- Transplants of Umbilical-Cord Blood or Bone Marrow from Unrelated Donors in Adults with Acute LeukemiaThe New England Journal of Medicine, 2004
- Outcomes after Transplantation of Cord Blood or Bone Marrow from Unrelated Donors in Adults with LeukemiaThe New England Journal of Medicine, 2004
- Liquid storage, shipment, and cryopreservation of cord bloodTransfusion, 2004
- Cord Blood Banking for Potential Future Transplantation: Subject ReviewPEDIATRICS, 1999
- Outcomes among 562 Recipients of Placental-Blood Transplants from Unrelated DonorsThe New England Journal of Medicine, 1998
- Hematopoietic Reconstitution in a Patient with Fanconi's Anemia by Means of Umbilical-Cord Blood from an HLA-Identical SiblingThe New England Journal of Medicine, 1989