Vasculitis Pathogenesis: Can We Talk About Precision Medicine?
Open Access
- 14 August 2018
- journal article
- review article
- Published by Frontiers Media SA in Frontiers in Immunology
- Vol. 9, 1892
- https://doi.org/10.3389/fimmu.2018.01892
Abstract
Precision medicine is designing the medical care by taking into account the individual variability for each person. We have tried to address whether the existing data may guide precision medicine in primary systemic vasculitides (PSV). We have reviewed genome-wide association studies (GWAS) data, lessons from monogenic mimics of these diseases, and biomarker studies in immunoglobulin A vasculitis/Henoch–Schönlein purpura, Kawasaki disease, anti-neutrophil cytoplasmic antibody-associated vasculitis, polyarteritis nodosa (PAN), Takayasu arteritis, and Behçet’s disease (BD). GWAS provide insights about the pathogenesis of PSV while whole exome sequencing studies lead to discovery of monogenic vasculitides, phenotype of which could mimic other types of vasculitis such as PAN and BD. Monogenic vasculitides form a subgroup of vasculitis which are caused by single gene alterations and discovery of these diseases has enabled more specific therapies in these patients. With increasing number of studies on biomarkers, new targets for treatment appear and better and structured follow-up of PSV patients will become possible. Proteomics and metabolomics studies are required to better categorize our patients with PSV so that we can manage them appropriately and offer more targeted therapy.Keywords
This publication has 138 references indexed in Scilit:
- Replication and Meta-Analysis of GWAS Identified Susceptibility Loci in Kawasaki Disease Confirm the Importance of B Lymphoid Tyrosine Kinase (BLK) in Disease SusceptibilityPLOS ONE, 2013
- Anti-Neutrophil Cytoplasmic Antibodies Stimulate Release of Neutrophil MicroparticlesJournal of the American Society of Nephrology, 2012
- Identification of Novel Susceptibility Loci for Kawasaki Disease in a Han Chinese Population by a Genome-Wide Association StudyPLOS ONE, 2011
- Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behçet's diseaseNature Genetics, 2010
- A CD8+ T cell transcription signature predicts prognosis in autoimmune diseaseNature Medicine, 2010
- Identification and Validation of Urinary Biomarkers for Differential Diagnosis and Evaluation of Therapeutic Intervention in Anti-neutrophil Cytoplasmic Antibody-associated VasculitisMolecular & Cellular Proteomics, 2009
- Netting neutrophils in autoimmune small-vessel vasculitisNature Medicine, 2009
- A Genome-Wide Association Study Identifies Novel and Functionally Related Susceptibility Loci for Kawasaki DiseasePLoS Genetics, 2009
- Identification of novel genetic susceptibility loci for Behçet's disease using a genome-wide association studyArthritis Research & Therapy, 2009
- Biomarkers and surrogate endpoints: Preferred definitions and conceptual frameworkClinical Pharmacology & Therapeutics, 2001