Anxiety Increases Acid-Induced Esophageal Hyperalgesia
- 1 October 2010
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Psychosomatic Medicine
- Vol. 72 (8), 802-809
- https://doi.org/10.1097/psy.0b013e3181f5c021
Abstract
Objective: Anxiety at the time of gastrointestinal injury or inflammation increases the risk of developing visceral hyperalgesia. Distal esophageal acidification induces hyperalgesia in the non-acid exposed proximal esophagus, due to the sensitization of spinal dorsal horn neurones. The objective was to determine whether anxiety influences acid-induced hyperalgesia.Keywords
This publication has 38 references indexed in Scilit:
- Severe gastro‐oesophageal reflux symptoms in relation to anxiety, depression and coping in a population‐based studyAlimentary Pharmacology & Therapeutics, 2007
- Oesophageal hypersensitivity is associated with features of psychiatric disorders and the irritable bowel syndromeAlimentary Pharmacology & Therapeutics, 2007
- Relationship Between Anxiety and Gastric Sensorimotor Function in Functional DyspepsiaPsychosomatic Medicine, 2007
- Stress-related changes in oesophageal permeability: filling the gaps of GORD?Gut, 2007
- Critical role of stress in increased oesophageal mucosa permeability and dilated intercellular spacesGut, 2007
- Influence of Experimentally Induced Anxiety on Gastric Sensorimotor Function in HumansGastroenterology, 2005
- Autonomic responses to heartburn induced by esophageal acid infusionJournal of Gastroenterology and Hepatology, 2004
- Superficial NK1-expressing neurons control spinal excitability through activation of descending pathwaysNature Neuroscience, 2002
- A new method of assessing cardiac autonomic function and its comparison with spectral analysis and coefficient of variation of R–R intervalJournal of the Autonomic Nervous System, 1997
- Analysis of serial measurements in medical research.BMJ, 1990