Detection rate of fluorine‐18‐fluorodeoxyglucose positron emission tomography in patients with marginal zone lymphoma of MALT type: a meta‐analysis
- 22 July 2014
- journal article
- research article
- Published by Wiley in Hematological Oncology
- Vol. 33 (3), 113-124
- https://doi.org/10.1002/hon.2152
Abstract
The aim of this article is to meta‐analyse published data about the detection rate (DR) of fluorine‐18‐fluorodeoxyglucose (18F‐FDG) positron emission tomography (PET) and PET/computed tomography (CT) in the evaluation of patients with marginal zone lymphoma of the mucosa‐associated lymphoid tissue (MALT). A comprehensive literature search of studies published through February 2014 was performed. Pooled DR of 18F‐FDG PET or PET/CT including 95% confidence intervals (95% CI) was calculated on a per‐patient‐based analysis. Twenty studies including 376 patients with MALT lymphoma were selected. The pooled DR of 18F‐FDG PET or PET/CT was 71% (95% CI: 61–80%). A significant difference between the DR of PET/CT (69%; 95% CI: 61–80%) and that of PET alone (73%; 95% CI: 60–84%) was not demonstrated. A better DR of 18F‐FDG PET or PET/CT in bronchial (94%; 95% CI: 85–99%) and head‐and‐neck (90%; 95% CI: 78–98%) MALT lymphomas compared with gastric (62%; 95% CI: 46–77%) and ocular (49%; 95% CI: 36–63%) MALT lymphomas was found. This meta‐analysis demonstrates that MALT lymphoma is an 18F‐FDG‐avid tumour in most of the cases, suggesting a potential clinical role of 18F‐FDG PET or PET/CT in the initial evaluation of these patients. In particular, the DR of 18F‐FDG PET or PET/CT is related to the primary site of the MALT lymphoma. Copyright © 2014 John Wiley & Sons, Ltd.Keywords
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