Connectivity sustains disease transmission in environments with low potential for endemicity: modelling schistosomiasis with hydrologic and social connectivities
Open Access
- 9 September 2008
- journal article
- research article
- Published by The Royal Society in Journal of The Royal Society Interface
- Vol. 6 (35), 495-508
- https://doi.org/10.1098/rsif.2008.0265
Abstract
Social interaction and physical interconnections between populations can influence the spread of parasites. The role that these pathways play in sustaining the transmission of parasitic diseases is unclear, although increasingly realistic metapopulation models are being used to study how diseases persist in connected environments. We use a mathematical model of schistosomiasis transmission for a distributed set of heterogeneous villages to show that the transport of parasites via social (host movement) and environmental (parasite larvae movement) pathways has consequences for parasite control, spread and persistence. We find that transmission can be sustained regionally throughout a group of connected villages even when individual village conditions appear not to support endemicity. Optimum transmission is determined by an interplay between different transport pathways, and not necessarily by those that are the most dispersive (e.g. disperse social contacts may not be optimal for transmission). We show that the traditional targeting of villages with high infection, without regard to village interconnections, may not lead to optimum control. These findings have major implications for effective disease control, which needs to go beyond considering local variations in disease intensity, to also consider the degree to which populations are interconnected.Keywords
This publication has 35 references indexed in Scilit:
- Individual and village‐level study of water contact patterns and Schistosoma japonicum infection in mountainous rural ChinaTropical Medicine & International Health, 2007
- Environmental effects on parasitic disease transmission exemplified by schistosomiasis in western ChinaProceedings of the National Academy of Sciences of the United States of America, 2007
- Schistosomiasis and water resources development: systematic review, meta-analysis, and estimates of people at riskThe Lancet Infectious Diseases, 2006
- Global Patterns of Influenza A Virus in Wild BirdsScience, 2006
- Use of quarantine in the control of SARS in SingaporeAmerican Journal of Infection Control, 2005
- Heterogeneous model of schistosomiasis transmission and long-term control: the combined influence of spatial variation and age-dependent factors on optimal allocation of drug therapyParasitology, 2004
- Spatial heterogeneity and the persistence of infectious diseasesJournal of Theoretical Biology, 2004
- Urban Access and Rural Productivity Growth in Post-Mao ChinaEconomic Development and Cultural Change, 1996
- Migrant workers and schistosomiasis in the Gezira, SudanTransactions of the Royal Society of Tropical Medicine and Hygiene, 1980
- Togetherness among Schistosomes: its effects on the dynamics of the infectionMathematical Biosciences, 1977