Chronic HCV infection and inflammation: Clinical impact on hepatic and extra-hepatic manifestations
- 1 January 2013
- journal article
- review article
- Published by Baishideng Publishing Group Inc. in World Journal of Hepatology
- Vol. 5 (10), 528-40
- https://doi.org/10.4254/wjh.v5.i10.528
Abstract
The liver has a central role in regulating inflammation by its capacity to secrete a number of proteins that control both local and systemic inflammatory responses. Chronic inflammation or an exaggerated inflammatory response can produce detrimental effects on target organs. Chronic hepatitis C virus (HCV) infection causes liver inflammation by complex and not yet well-understood molecular pathways, including direct viral effects and indirect mechanisms involving cytokine pathways, oxidative stress and steatosis induction. An increasing body of evidence recognizes the inflammatory response in chronic hepatitis C as pathogenically linked to the development of both liver-limited injury (fibrosis, cirrhosis and hepatocellular carcinoma) and extrahepatic HCV-related diseases (lymphoproliferative disease, atherosclerosis, cardiovascular and brain disease). Defining the complex mechanisms of HCV-induced inflammation could be crucial to determine the global impact of infection, to estimate progression of the disease, and to explore novel therapeutic approaches to avert HCV-related diseases. This review focuses on HCV-related clinical conditions as a result of chronic liver and systemic inflammatory states.Keywords
This publication has 127 references indexed in Scilit:
- Hepatitis C virus activates interleukin-1β via caspase-1-inflammasome complexJournal of General Virology, 2012
- Host Response to Translocated Microbial Products Predicts Outcomes of Patients With HBV or HCV InfectionGastroenterology, 2011
- Nitric Oxide and Redox Regulation in the Liver: Part I. General Considerations and Redox Biology in HepatitisJournal of Surgical Research, 2010
- Hepatitis C Virus Infection and the Risk of Coronary DiseaseClinical Infectious Diseases, 2009
- Association of Hepatitis C Virus Seropositivity With Inflammatory Markers and Heart Failure in Persons With Coronary Heart Disease: Data From the Heart and Soul StudyJournal of Cardiac Failure, 2009
- Endocannabinoids and the Control of Energy HomeostasisPublished by Elsevier BV ,2008
- Obesity and steatosis influence serum and hepatic inflammatory markers in chronic hepatitis CHepatology, 2008
- TNFα-induced sickness behavior in mice with functional 55 kD TNF receptors is blocked by central IGF-IJournal of Neuroimmunology, 2007
- The Molecular Basis for Oxidative Stress-Induced Insulin ResistanceAntioxidants and Redox Signaling, 2005
- Structural biology of hepatitis C virusHepatology, 2004