Infant Gut Microbiota Development Is Driven by Transition to Family Foods Independent of Maternal Obesity
Open Access
- 25 February 2016
- journal article
- research article
- Published by American Society for Microbiology in mSphere
- Vol. 1 (1), e00069-15
- https://doi.org/10.1128/msphere.00069-15
Abstract
The potential influence of maternal obesity on infant gut microbiota may occur either through vertically transmitted microbes or through the dietary habits of the family. Recent studies have suggested that the heritability of obesity may partly be caused by the transmission of “obesogenic” gut microbes. However, the findings presented here suggest that maternal obesity per se does not affect the overall composition of the gut microbiota and its development after introduction of complementary foods. Rather, progression in complementary feeding is found to be the major determinant for gut microbiota establishment. Expanding our understanding of the influence of complementary diet on the development and establishment of the gut microbiota will provide us with the knowledge to tailor a beneficial progression of our intestinal microbial community.Keywords
Funding Information
- Danish Council for Strategic Research (0603-00579b)
- Danish Council for Strategic Research (11-116163)
This publication has 55 references indexed in Scilit:
- Human gut microbiome viewed across age and geographyNature, 2012
- Linking Long-Term Dietary Patterns with Gut Microbial EnterotypesScience, 2011
- Succession of microbial consortia in the developing infant gut microbiomeProceedings of the National Academy of Sciences of the United States of America, 2010
- Nursing our microbiota: molecular linkages between bifidobacteria and milk oligosaccharidesTrends in Microbiology, 2010
- Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newbornsProceedings of the National Academy of Sciences of the United States of America, 2010
- Genomic and metabolic adaptations of Methanobrevibacter smithii to the human gutProceedings of the National Academy of Sciences of the United States of America, 2007
- Mechanisms underlying the resistance to diet-induced obesity in germ-free miceProceedings of the National Academy of Sciences of the United States of America, 2007
- Human gut microbes associated with obesityNature, 2006
- An obesity-associated gut microbiome with increased capacity for energy harvestNature, 2006
- Obesity alters gut microbial ecologyProceedings of the National Academy of Sciences of the United States of America, 2005